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Papers on “epigenetics gene expression disease”

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  1. From Environment to Gene Expression: Epigenetics and the Development of Mental Health Disorders

    Jennings Hernandez · 2023 · International Neuropsychiatric Disease Journal · 2 cites

    Psychiatric disorders have multifaceted origins, involving a combination of genetic and environmental factors that contribute significantly to their development. In recent times, researchers have emphasized the role of epigenetic mechanisms as the underlying molecular foundation for how environmental factors influence biological processes. Consequently, the field of epigenetics has gained growing prominence within the realm of psychiatry as a means to understand these intricate connections. This qualitative research paper explores the role of epigenetics in mental health disorders, focusing on the impact of environmental factors on gene expression. By examining the complex interplay between

  2. Epigenetics: The Impact of Trauma on Gene Expression and Transgenerational Transmission

    Sama A. Akbarli, Chilanay M. Alakbarova · 2026 · Journal of Molecular Biosciences and Engineering

    This study examines the relationship between childhood trauma and epigenetic changes in genes that regulate the stress response. Traumas such as violence or lack of control experienced at an early age can disrupt the long-term regulatory mechanisms of the hypothalamic-pituitary-adrenal (HPA) axis, leading to impaired stress responses. Epigenetic mechanisms such as DNA methylation, histone modifications, and non-coding RNAs play an important role in the stress response by regulating gene expression without altering the DNA sequence. Genes such as FKBP5, MAOA, and NR3C1, which are important in stress regulation, are sensitive to childhood trauma; changes in their methylation and transcription

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