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Papers on “placebo effect mechanisms clinical trials”

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1. Mechanisms of the placebo response and their impact on clinical trials and clinical practice

   Damien G. Finniss, Fabrizio Benedetti · 2005 · Pain · 121 cites

2. Placebo Effect and Clinical Trials in Migraine Therapy

   James R. Couch, Jr. · 1987 · Neuroepidemiology · 38 cites

   Migraine is a cyclical condition in which the cycles may occur or remit in an unpredictable fashion. The goal of prophylactic antimigraine therapy is to induce remission of an active cycle of migraine or to inhibit occurrence of individual headaches until the cycle remits for other reasons. The placebo effect probably takes advantage of these cycles. The placebo effect is significant and quite potent. The placebo effect may be divided into (1) the initial effect and (2) the continuing effect which is seen following a stabilization period. The initial placebo effect is dramatic with 62% of 188 subjects improving by 75% after 4 weeks of placebo. The continuing effect is demonstrated by occurre

3. Importance of Placebo Effect in Cough Clinical Trials

   Ron Eccles · 2010 · Lung · 30 cites

4. Justice for Placebo: Placebo Effect in Clinical Trials and Everyday Practice

   Nebojsa Nick Knezevic, Aleksandar Sic, Samantha Worobey, et al. · 2025 · Medicines · 23 cites

   The placebo effect has been widely documented across various medical conditions, demonstrating its ability to influence both subjective and objective outcomes. Placebo responses can significantly improve symptoms in these different conditions, such as pain, Parkinson’s disease, depression, anxiety, and addiction. Psychological mechanisms, particularly the power of patient expectations, appear to play a central role, with neurobiological evidence supporting the activation of dopamine, endogenous opioids, and endocannabinoids in response to placebo interventions. Studies have demonstrated that placebo injections and more complex procedures, including sham surgeries, can produce therapeutic eff

5. When are placebo-controlled trials no longer appropriate?

   Baruch A. Brody · 1997 · Controlled Clinical Trials · 21 cites

6. Reliable differences in placebo effects between clinical analgesic trials and studies of placebo analgesia mechanisms

   D D. Price, L J. Riley, L Vase · 2003 · Pain · 17 cites

7. Unreliable analysis of placebo analgesia in trials of placebo pain mechanisms

   Asbjørn Hróbjartsson, Peter C Gøtzsche · 2003 · Pain · 13 cites

8. Who controls the placebo? Introducing a Placebo Quality Checklist for pharmacological trials

   Benno Brinkhaus, Daniel Pach, Rainer Lüdtke, et al. · 2008 · Contemporary Clinical Trials · 12 cites