Health · Literature

Research papers on Intermittent fasting and metabolism

Recent and highly-cited academic work on intermittent fasting and metabolism, gathered from Semantic Scholar, CrossRef and OpenAlex.

1. Metabolic Effects of Intermittent Fasting

   Ruth E. Patterson, Dorothy D. Sears · 2017 · Annual Review of Nutrition · 805 citations

   The objective of this review is to provide an overview of intermittent fasting regimens, summarize the evidence on the health benefits of intermittent fasting, and discuss physiological mechanisms by which intermittent fasting might lead to improved health outcomes. A MEDLINE search was performed using PubMed and the terms "intermittent fasting," "fasting," "time-restricted feeding," and "food timing." Modified fasting regimens appear to promote weight loss and may improve metabolic health. Several lines of evidence also support the hypothesis that eating patterns that reduce or eliminate nighttime eating and prolong nightly fasting intervals may result in sustained improvements in human hea

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2. Intermittent Fasting and Metabolic Health

   Izzah Vasim, Chaudry Nasir Majeed, Mark Daniel DeBoer · 2022 · Nutrients · 285 citations

   Given the ongoing strain that the obesity epidemic has placed on public health outcomes, new and effective approaches to weight control are needed. One approach to improving weight and metabolic outcomes is intermittent fasting, which consists of multiple different timing schedules for temporary food avoidance, including alternate-day fasting, other similar full-day fasting patterns, and time-restricted feeding (where the day's food is consumed over a 6-h period, allowing for 18 h of fasting). These feeding schedules have favorable metabolic effects by intermittently inducing the metabolism of fatty acids to ketones. The regimens overall lead to a decrease in weight and have been linked to i

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3. Intermittent Fasting and Metabolic Health: From Religious Fast to Time-Restricted Feeding

   K. Hoddy, K. Marlatt, Hatice Çetinkaya, et al. · 2020 · Obesity (Silver Spring, Md.) · 116 citations

   Over the past 10 to 15 years, intermittent fasting has emerged as an unconventional approach to reduce body weight and improve metabolic health beyond simple calorie restriction. In this review, we summarize findings related to Ramadan and Sunnah fasting. We then discuss the role of caloric restriction not only as an intervention for weight control, but importantly, as a strategy for healthy aging and longevity. Finally, we review the four most common intermittent fasting (IF) strategies used to date for weight management and to improve cardiometabolic health. Weight loss is common after IF but does not appear to be different than daily caloric restriction when compared directly. IF may also

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4. The role of intermittent fasting and meal timing in weight management and metabolic health

   Iain Templeman, Javier Thomas Gonzalez, Dylan Thompson, et al. · 2019 · Proceedings of The Nutrition Society · 86 citations

   Obesity remains a major public health concern and intermittent fasting is a popular strategy for weight loss, which may present independent health benefits. However, the number of diet books advising how fasting can be incorporated into our daily lives is several orders of magnitude greater than the number of trials examining whether fasting should be encouraged at all. This review will consider the state of current understanding regarding various forms of intermittent fasting (e.g. 5:2, time-restricted feeding and alternate-day fasting). The efficacy of these temporally defined approaches appears broadly equivalent to that of standard daily energy restriction, although many of these models

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5. Intermittent Fasting Regulates Metabolic Homeostasis and Improves Cardiovascular Health

   Rawan Diab, Lina Dimachkie, Omar Zein, et al. · 2024 · Cell Biochemistry and Biophysics · 31 citations

   Obesity is a leading cause of morbidity and mortality globally. While the prevalence of obesity has been increasing, the incidence of its related complications including dyslipidemia and cardiovascular disease (CVD) has also been rising. Recent research has focused on modalities aimed at reducing obesity. Several modalities have been suggested including behavioral and dietary changes, medications, and bariatric surgery. These modalities differ in their effectiveness and invasiveness, with dietary changes gaining more interest due to their minimal risks compared to other modalities. Specifically, intermittent fasting (IF) has been gaining interest in the past decade. IF is characterized by cy

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6. [Intermittent fasting and human metabolic health].

   V. Carvajal, A. Marín, Daniela Gihardo, et al. · 2023 · Revista medica de Chile · 15 citations

   Intermittent fasting (IF) has gained increasing scientific and general attention. Most studied forms of IF include alternate-day fasting, modified alternate-day fasting, and time-restricted eating (TRE). Several cardiometabolic effects of IF have been described in animal models and, to a lesser extent, in humans. This review analyzes the impact of IF on weight loss, glucose metabolism, blood pressure, and lipid profile in humans. A literature search was conducted in the Pubmed/Medline, Scopus, and Google Scholar databases. Controlled observational or interventional studies in humans, published between January 2000 and June 2021, were included. Studies comparing IF versus religious fasting we

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7. Intermittent fasting, exercise and dietary modification induce unique transcriptomic signatures of multiple tissues governing metabolic homeostasis during weight loss and rebound weight gain.

   Tianqi Liu, Yuan Liu, Tao Yan, et al. · 2024 · The Journal of nutritional biochemistry · 15 citations

   Obesity and its related metabolic diseases bring great challenges to public health. In-depth understanding on the efficacy of weight-loss interventions is critical for long-term weight control. Our study demonstrated the comparable efficacy of exercise (EX), intermittent fasting (IF), or the change of daily diet from an unhealthy to a normal chow (DR) for weight reduction, but largely divergently affected metabolic status and transcriptome of subcutaneous fat, scapular brown fat, skeletal muscles and liver in high-fat-high-fructose diet (HFHF) induced obese mice. EX and IF reduced systematic inflammation, improved glucose and lipid metabolism in liver and muscle, and amino acid metabolism an

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8. Intermittent fasting for weight management and metabolic health: An updated comprehensive umbrella review of health outcomes

   Zixin Hua, Siyu Yang, Jun Li, et al. · 2024 · Diabetes Obesity and Metabolism · 10 citations

   AIMS: To provide an updated comprehensive evaluation of the quality and evidence association of existing studies on health outcomes related to intermittent fasting (IF). MATERIALS AND METHODS: We conducted a systematic search of PubMed, Web of Science, Cochrane Library, and Embase databases, covering literature up to June 2024. Meta-analyses and systematic reviews that include adult populations and quantitatively analyse health outcomes related to IF interventional studies are included. For evidence with complete data, we reanalyzed health evidence effect sizes and 95% confidence intervals using random-effects models. Article quality and the certainty of the evidence were graded using A Meas

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9. Sports Performance and Intermittent Fasting: Impact on Training and Results, Mechanisms and Health Benefits in Weight Management, Metabolic Health, and Chronic Diseases – A Review of Risks, Current Evidence, and Future Research Directions

   Mateusz Bieńko, Marta Rutkowska, Tomasz Król, et al. · 2024 · Quality in Sport · 2 citations

   Introduction: Intermittent Fasting (IF) has become a popular method in the contemporary medical world as an up-to date technique of the health and wellbeing in the last several years. Purpose: This research aims to investigate the both impact of IF on sports performance and therapeutic potential of IF on cardiovascular, metabolic and neurological diseases with focus on obesity, diabetes and impact on cardiometabolic risk. State of Knowledge: Intermittent fasting has been found to extend both life and health span by positively impacting weight management, reducing the risk of cardiovascular incidents, promoting cellular repair, and exhibiting anti-inflammatory actions. It improves blood

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10. The impact of Intermittent Fasting on Weight Loss and Metabolic Health - a review of the latest research

    Marta Justyna Gonciarz, Dominika Karolina Adamiec, Anna Dąbrowska, et al. · 2024 · Quality in Sport · 2 citations

    Introduction and purpose Intermittent fasting (IF) is a dietary pattern that alternates between periods of fasting or reduced caloric intake and periods of unrestricted eating. There are three primary types of IF: Alternate Day Fasting (ADF), Time-Restricted Eating (TRE), and Periodic Fasting (PF). This review article summarizes the impact of IF on weight loss. Additionally, it examines the broader health effects of IF, including its influence on cardiovascular risk, diabetes management, and neurodegenerative diseases. Description of the state of knowledge Fasting, the practice of abstaining from or limiting food intake for a specified period, has been a cultural and religious tradition worl

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11. Assessing the impact of intermittent fasting and a low-carbohydrate-high-protein diet on metabolic health and pancreatic histopathology in type 2 diabetic rat model

    Arwa M. Alqusayer, W. Ahmed, S. Althwab, et al. · 2025 · International Journal of Health Sciences · 2 citations

    ABSTRACT Objective: The current study was conducted to investigate the effect of intermittent fasting (IF) with a low-carbohydrate-high-protein (LCHP) diet on blood glucose control in streptozotocin (STZ)-nicotinamide-induced type 2 diabetic rats (DR). Methods: Thirty male Wistar rats were divided into six groups (n = 5) including a group of normal rats (NR) that received a control diet (CD) (50% carbohydrates, 17% protein, and 33% fat) with ad libitum (AL) feeding. The remaining 5 groups were DR injected with STZ and fed on CD or LCHP diet (40% carbohydrates, 30% protein, and 30% fat) for 6 weeks, either AL or IF (with a time-restricted feeding of 16 h followed by 8 h feeding period). There

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12. Dapagliflozin-intermittent fasting combination maximizes weight and metabolic regulation through AMPK/sirtuins/clock genes and gut microbiota signaling in high-fat diet-induced obesity: a novel anti-obesity approach

    Mahmoud A. Senousy, Rana Mohamed Abo-Elmaaty, Nesreen Nabil Omar, et al. · 2026 · Cell & Bioscience · 2 citations

    Innovative and affordable treatment options are required to combat obesity and its detrimental impact on health economics. Dapagliflozin (Dapa), an antidiabetic medication, promotes weight loss; however, the extent of weight reduction may be limited. Intermittent fasting (IF) is a dietary approach regarded as a cost-effective and readily accessible regimen. This study investigated the beneficial effects of Dapa, IF, and their combination on weight loss and metabolic derangements in high-fat diet (HFD)-induced obesity in rats. Male Sprague-Dawley rats were allocated into 6 groups: groups 1 (normal control) and 2 (drug control) were administered a normal chow diet, while the obesity groups 3,

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13. Effects of Intermittent Fasting on Weight Loss and Cardiometabolic Health

    Rümeysa GERBOĞA, Cansu BEKAR · 2023 · Current Perspectives on Health Sciences · 2 citations

    Intermittent fasting is a cyclical way of eating that is formed by the succession of eating and fasting period. It includes a long period of fasting, such as 16-48 hours, in which individuals receive little or no energy, and a normal eating period. The most commonly applied methods are alternate day fasting (ADF), time-restricted feeding (TRF) the 5:2 diet and Ramadan fasting. It has been reported that these diet models can be an alternative to continuous energy restriction in the medical nutrition treatment of obesity and are effective in weight loss. Intermittent fasting can have positive effects on reducing the risk of cardiovascular diseases and improving symptoms by causing reductions i

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14. Effects of Intermittent Fasting on Weight Loss and Metabolic Health

    Anna Kaźmierczak, Klaudia Perkowska, Anna Kiełb, et al. · 2024 · Quality in Sport · 1 citations

    Introduction and Purpose: Intermittent fasting (IF) has become a popular strategy for combating obesity and improving metabolic health. This dietary regimen alternates between periods of fasting and eating, aiming to enhance cellular health and increase longevity. With obesity rates doubling globally since 1990 and metabolic diseases on the rise, IF offers a potential solution by promoting metabolic benefits and reducing obesity-related conditions. Material and Method: This review examines various IF methods, including alternate-day fasting, the 5:2 diet, and time-restricted eating. The analysis focuses on the impact of these fasting methods on body weight, insulin sensitivity, and lipid pro

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15. “Intermittent Fasting and Type 2 Diabetes: Impacts on Glycemic Control and Metabolic Health

    Tvisa Punyatoya, B. S. · 2025 · International Journal For Multidisciplinary Research · 1 citations

    Type 2 Diabetes Mellitus (T2DM) remains a growing global health challenge, driven by increasing obesity, poor dietary patterns, and sedentary lifestyles. In recent years, intermittent fasting (IF) has emerged as a promising non-pharmacological intervention for improving glycemic control and metabolic outcomes in T2DM patients. This review explores the mechanisms linking IF to enhanced insulin sensitivity, reduced oxidative stress, circadian regulation, and metabolic flexibility. Clinical trials and meta-analyses have demonstrated significant improvements in HbA1c, fasting glucose, weight loss, and insulin resistance with various IF regimens such as time restricted eating (TRE), alternate-da

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16. Long-term Effects of Intermittent Fasting on Weight Loss and Metabolic Risk Factors: A Systematic Review of Randomized Controlled Trials

    Eleni Vlastaridou, Sofia Blatsiou, Ioanna Kosma, et al. · 2025 · Journal of Atherosclerosis Prevention and Treatment · 1 citations

    Obesity is rising globally, posing public health challenges and highlighting the need for effective, evidence-based dietary interventions. Intermittent fasting (IF), involving alternating periods of eating and fasting, is a promising alternative to continuous energy restriction (CER) for metabolic health. This systematic review evaluated the long-term effects (≥12 months) of IF compared with control diets on body weight and markers of metabolic health in adults with overweight or obesity. MEDLINE/PubMed and Scopus were systematically searched through July 2025 following Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, and study quality was assessed using the C

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17. Intermittent Fasting: Effects on Weight Loss, Metabolic Health, and Cognitive Function – A Systematic Review

    İpek Türkmen · 2024 · Next generation.

    Intermittent fasting (IF) has gained widespread attention as a dietary strategy for weight loss and improving overall health. This systematic review aims to evaluate the effects of intermittent fasting on weight loss, metabolic health, and cognitive function by analyzing data from various clinical trials and studies. The review compares different intermittent fasting protocols, such as time-restricted eating, alternate-day fasting, and the 5:2 diet, and examines their impact on body weight, fat loss, insulin sensitivity, cholesterol levels, and inflammation markers. Additionally, the review explores the potential cognitive benefits of intermittent fasting, focusing on improvements in memory,

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18. ROLE OF INTERMITTENT FASTING ON METABOLIC HEALTH IN OVERWEIGHT ADULTS A NARRATIVE REVIEW

    Akif Saeed Ch, Naheed Shah, Shaikh khalid Muhammad, et al. · 2025 · Insights-Journal of Health and Rehabilitation

    Background: Intermittent fasting (IF) has emerged as a widely practiced dietary strategy with growing scientific interest for its potential role in managing obesity and improving metabolic health. With global rates of overweight and obesity rising at an alarming pace, effective non-pharmacologic interventions are increasingly needed to address associated metabolic disorders such as insulin resistance, dyslipidemia, and impaired glucose regulation. Objective: This narrative review aims to explore the metabolic effects of intermittent fasting in overweight and obese adults, highlighting its clinical benefits, potential limitations, and areas requiring further investigation. Main Discussion Poi

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19. Unlocking Health: The Rise of Intermittent Fasting for Weight Loss and Metabolic Wellness

    S. Ghosh, John M. Abraham, E. Lakshmi · 2024 · International Journal of Pharma and Bio Sciences

    Intermittent fasting (IF), encompassing methods like alternate-day fasting (ADF), the 5:2 diet, and time-restricted feeding (TRF), has garnered significant attention for its potential health benefits. TRF involves consuming food within an 8-hour daily window, leading to metabolic shifts and adaptive responses in the brain and nervous system. IF often results in reduced calorie intake, similar to calorie restriction (CR) regimens in laboratory studies. IF also promotes autophagy, reducing inflammation and oxidative stress and lowering the health risk of chronic diseases like cancer and neurodegenerative disorders. IF may enhance sleep quality and duration by aligning eating patterns with circ

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20. The Impact of Intermittent Fasting on Metabolic Health and Chronic Disease Prevention: A Comprehensive Review

    Arisa Tantirasmee · 2024 · International Journal of Current Science Research and Review

    Intermittent fasting has gained attention as a dietary approach focusing on the timing of eating rather than the specific foods being consumed. Unlike the traditional calorie restriction, intermittent fasting involves alternating periods of fasting and eating. Several prevalent forms of IF exist, each with unique fasting durations and eating windows. For instance, the 16/8 method restricts food intake to an 8-hour window each day, followed by 16 hours of fasting. The 5:2 diet involves eating regular meals for five days a week and significantly reducing calorie intake to 500-600 calories on the remaining two non-consecutive days. Another popular method, Eat-Stop-Eat, includes one or two 24-ho

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21. Dynamic impact of intermittent fasting and refeeding on metabolic health and microbiome-metabolome signatures in cynomolgus monkeys.

    Libing Xu, Liying Guo, Qunchao Su, et al. · 2026 · Journal of advanced research

    INTRODUCTION Dietary intervention has emerged as a promising approach for improving metabolic health across species; however, its systemic effects in non-human primates (NHPs) remain insufficiently characterized. OBJECTIVES We sought to investigate the metabolic and physiological impacts of time-restricted intermittent fasting (IF) regimen that resulted in a net energy deficit in overweight female cynomolgus monkeys, both during the intervention and after dietary reversal, with particular focus on body weight, metabolic parameters, immune cell ratios, gut microbiota, and serum metabolomic profiles. METHODS Overweight monkeys underwent 20-hour fasting/4-hour feeding IF protocol for 84 day

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22. Exploring the Interconnected Pathways of Intermittent Fasting, Weight, and Education on Basal Metabolic Index:A Structural Equation Model

    C. Vargas · 2025 · International Journal of Scientific Research and Management (IJSRM)

    This study investigates the correlation between Intermittent Fasting (IF), Weight Efficacy Lifestyle (WEL) scores, and weight, with education considered as a potential mediating variable, and their combined impact on the Basal Metabolic Index (BMI) among Filipinos. Intermittent fasting has gained popularity as a weight management strategy, yet its effects may vary depending on individual factors such as educational attainment, lifestyle, and health awareness. To explore these relationships, data were collected from 200 respondents across Region X, Philippines, utilizing the standardized Weight Efficacy Lifestyle (WEL) Survey Questionnaire. Descriptive and correlational analyses were performe

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23. INTERMITTENT FASTING AND CHRONONUTRITION: SYNERGISTIC APPROACHES FOR METABOLIC HEALTH

    Andressa dos Reis Gonçalves Mariani · 2023 · Revista Sistemática

    Intermittent fasting (IF) and chrononutrition are emerging dietary strategies that align eating patterns with human circadian rhythms to improve metabolic health. While intermittent fasting emphasizes extended periods without caloric intake, chrononutrition focuses on the timing of food consumption relative to biological clocks. Both approaches have been associated with improvements in insulin sensitivity, lipid metabolism, and weight management. Evidence suggests that meal timing plays a critical role in regulating circadian physiology, influencing hormone secretion, glucose metabolism, and energy expenditure. Integrating principles of IF and chrononutrition may provide synergistic benefits

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24. Author response for "Intermittent fasting for weight management and metabolic health: An updated comprehensive umbrella review of health outcomes"

    Zixin Hua, Siyu Yang, Jing Li, et al. · 2024

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