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Research papers on Stem cell therapy

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  1. Stem Cells: A Revolution in Therapeutics—Recent Advances in Stem Cell Biology and Their Therapeutic Applications in Regenerative Medicine and Cancer Therapies

    Murielle Mimeault, Ralph J. Hauke, Surinder K. Batra · 2007 · Clinical Pharmacology & Therapeutics · 450 citations

    Basic and clinical research accomplished during the last few years on embryonic, fetal, amniotic, umbilical cord blood, and adult stem cells has constituted a revolution in regenerative medicine and cancer therapies by providing the possibility of generating multiple therapeutically useful cell types. These new cells could be used for treating numerous genetic and degenerative disorders. Among them, age-related functional defects, hematopoietic and immune system disorders, heart failures, chronic liver injuries, diabetes, Parkinson's and Alzheimer's diseases, arthritis, and muscular, skin, lung, eye, and digestive disorders as well as aggressive and recurrent cancers could be successfully tr

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  3. Mesenchymal stem cell‐based therapy: a new paradigm in regenerative medicine

    Neeraj Kumar Satija, Vimal Kishor Singh, Yogesh Kumar Verma, et al. · 2009 · Journal of Cellular and Molecular Medicine · 252 citations

    Mesenchymal stem cells (MSCs), adherent fibroblastoid cells, present in bone marrow and many other tissues can be easily isolated and expanded in vitro. They are capable of differentiating into different cell types such as osteoblasts, chondrocytes, adipocytes, cardiomyocytes, hepatocytes, endothelial cells and neuronal cells. Such immense plasticity coupled with their ability to modulate the activity of immune cells makes them attractive for stem cell-based therapy aimed at treating previously incurable disorders. Preclinical studies have reported successful use of MSCs for delivering therapeutic proteins and repairing defects in a variety of disease models. These studies highlighted the in

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  4. Clinical utility of mesenchymal stem/stromal cells in regenerative medicine and cellular therapy

    Vitali V. Maldonado, Neel H Patel, Emma E. Smith, et al. · 2023 · Journal of Biological Engineering · 112 citations

    Mesenchymal stem/stromal cells (MSCs) have been carefully examined to have tremendous potential in regenerative medicine. With their immunomodulatory and regenerative properties, MSCs have numerous applications within the clinical sector. MSCs have the properties of multilineage differentiation, paracrine signaling, and can be isolated from various tissues, which makes them a key candidate for applications in numerous organ systems. To accentuate the importance of MSC therapy for a range of clinical indications, this review highlights MSC-specific studies on the musculoskeletal, nervous, cardiovascular, and immune systems where most trials are reported. Furthermore, an updated list of the di

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  5. Embryonic stem cell transplantation: potential applicability in cell replacement therapy and regenerative medicine

    C Wu Douglas · 2007 · Frontiers in bioscience · 106 citations

    Embryonic stem cells are derived from the inner cell mass of the trophoblast, and have the ability to differentiate into all the tissues of the fetus. As such, their potential in cell replacement therapy and regenerative medicine has been widely acknowledged. Useful cell types such as neurons, cardiomyocytes, hepatocytes, pancreatic beta cells, and blood cells have all been successfully derived in the laboratory. Furthermore, embryonic stem cells may be utilized in novel immunomodulatory applications, such as hematopoietic chimerism strategies aimed at inducing tolerance to donor organ allografts. Unfortunately, progress in embryonic stem cell therapeutics continues to be hindered by haphaza

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  6. Prospect of Stem Cell Therapy and Regenerative Medicine in Osteoporosis

    Babak Arjmand, Masoumeh Sarvari, Sepideh Alavi-Moghadam, et al. · 2020 · Frontiers in Endocrinology · 93 citations

    The field of cell therapy and regenerative medicine can hold the promise of restoring normal tissues structure and function. Additionally, the main targets of stem cell-based therapies are chronic diseases and lifelong disabilities without definite cures such as osteoporosis. Osteoporosis as one of the important causes of morbidity in older men and post-menopausal women is characterized by reduced bone quantity or skeletal tissue atrophy that leads to an increased risk of osteoporotic fractures. The common therapeutic methods for osteoporosis only can prevent the loss of bone mass and recover the bone partially. Nevertheless, stem cell-based therapy is considered as a new approach to regener

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  7. Translating stem cell therapies: The role of companion animals in regenerative medicine

    Susan W. Volk, Christine L. Theoret · 2013 · Wound Repair and Regeneration · 92 citations

    Veterinarians and veterinary medicine have been integral to the development of stem cell therapies. The contributions of large animal experimental models to the development and refinement of modern hematopoietic stem cell transplantation were noted nearly five decades ago. More recent advances in adult stem cell/regenerative cell therapies continue to expand knowledge of the basic biology and clinical applications of stem cells. A relatively liberal legal and ethical regulation of stem cell research in veterinary medicine has facilitated the development and in some instances clinical translation of a variety of cell-based therapies involving hematopoietic stem cells and mesenchymal stem cell

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  10. Enhancing regenerative medicine: the crucial role of stem cell therapy

    Jipeng Wang, Gang Deng, Shuyi Wang, et al. · 2024 · Frontiers in Neuroscience · 46 citations

    Stem cells offer new therapeutic avenues for the repair and replacement of damaged tissues and organs owing to their self-renewal and multipotent differentiation capabilities. In this paper, we conduct a systematic review of the characteristics of various types of stem cells and offer insights into their potential applications in both cellular and cell-free therapies. In addition, we provide a comprehensive summary of the technical routes of stem cell therapy and discuss in detail current challenges, including safety issues and differentiation control. Although some issues remain, stem cell therapy demonstrates excellent potential in the field of regenerative medicine and provides novel tact

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  13. Stem cell therapies and regenerative medicine in China

    Sha Huang, Xiaobing Fu · 2014 · Science China Life Sciences · 18 citations

    Stem cells are the core of tissue repair and regeneration, and a promising cell source for novel therapies. In recent years, research into stem cell therapies has been particularly exciting in China. The remarkable advancements in basic stem cell research and clinically effective trials have led to fresh insights into regenerative medicine, such as treatments for sweat gland injury after burns, diabetes, and liver injury. High hopes have inspired numerous experimental and clinical trials. At the same time, government investment and policy support of research continues to increase markedly. However, numerous challenges must be overcome before novel stem cell therapies can achieve meaningful c

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  15. Stem cell therapy in regenerative medicine

    Jaroslav Michálek · 2020 · Journal of Stem Cell Biology and Transplantation · 3 citations

    More than 90% of all diseases are chronic, long lasting. At the beginning of the 21-st century the concept of regenerative medicine has been raised leading to more natural cures using and optimizing the capacity of human body and each cell in the body for self healing. Stem cell therapy as a new perspective, save and novel treatment option has demonstrated safety and clinical efficacy in many chronic medical conditions that are not curable by the means of chemical drugs. Here we would like to show our experience with clinical application of stem cells and other regenerative cells obtained from stromal vascular fraction (SVF) of adipose tissue. Since 2011, more than 3500 patients were success

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  17. Advances in Stem Cell Therapy: A Hope for Regenerative Medicine

    Naveed Shuja · 2024 · DEVELOPMENTAL MEDICO-LIFE-SCIENCES

    Introduction Regenerative medicine has become a light at the end of the tunnel for countless patients who have suffered from diseases previously considered incurable. Stem cell therapy is central to this revolutionary progress and has already made huge advances in recent years. Stem cells have the potential to regenerate tissues, repair organs, and even modulate immune responses, making them a key to delivering innovative treatments for a broad spectrum of medical conditions. This editorial describes recent progress in stem cell therapy as well as its promise as a regenerative medicine[1]. Stem Cells have unique Properties. Stem cells have unique properties that make them of great value in t

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  18. Stem Cell Therapy in Multiple Sclerosis: Regenerative Treatment for Neurological Repair

    Thomas Faile, Vincent S Gallicchio · 2024 · Stem Cell and Regenerative Medicine

    Multiple sclerosis is a chronic autoimmune and neurodegenerative disease, which primarily affects the central nervous system. The purpose of this study was to collectively evaluate the efficiency and safety of a variety of stem cell therapies in clinical studies concerning multiple sclerosis. The findings of this research investigating the treatment options indicate that stem cell therapy of a variety of types hold promise as a treatment option of MS. The most frequently researched stem cells, MSCs and HSCs, primarily provide reduction in inflammation and uncontrollable immune response, with improvements in remyelination and motor function testing. Additionally, stem cell therapy has led to

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  20. Regenerative Longevity Medicine: Hyperbaric Oxygen Therapy as a Cornerstone for Healthy Aging

    Miguel G Garber · 2025 · Stem Cell and Regenerative Medicine

    Regenerative longevity medicine is revolutionizing healthcare by targeting the biological mechanisms of aging to extend healthspan and improve quality of life. This article critically examines the integration of hyperbaric oxygen therapy (HBOT) into regenerative medicine, emphasizing its role in cellular repair, inflammation reduction, and cognitive enhancement. Despite evidence supporting its efficacy in modulating biological aging markers such as telomere length and cellular senescence, HBOT remains underrepresented in longevity medicine discourse. We argue for the necessity of including HBOT in regenerative strategies and explore its synergistic potential with interventions like stem cell

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  22. Systemic Lupus Erythematosus & Stem Cell Therapy

    Samantha Albano, Vincent S Gallicchio · 2023 · Stem Cell and Regenerative Medicine

    Systemic lupus erythematosus is an autoimmune disease characterized by a diverse range of clinical presentation and severe complications involving multiple organ systems. The global prevalence of this disorder ranges from 13 to 7713.5 per 100 000 individuals, with non-Caucasian women at the highest risk of developing the disease. SLE is a social as well as public health problem as this condition ranks among one of the top twenty leading causes of death in females from the age of five to sixty-four years of age and current treatments using multidisciplinary approaches can only work to control symptoms and further progression of disease while no true cure exists. Recent studies involving stem

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