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Research papers on Synthetic biology

Recent and highly-cited academic work on synthetic biology, gathered from Semantic Scholar, CrossRef and OpenAlex.

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  4. Preparing synthetic biology for the world

    Gerd H. G. Moe-Behrens, René Daer, Karmella Ann Haynes · 2013 · Frontiers in Microbiology · 160 citations

    Synthetic Biology promises low-cost, exponentially scalable products and global health solutions in the form of self-replicating organisms, or "living devices." As these promises are realized, proof-of-concept systems will gradually migrate from tightly regulated laboratory or industrial environments into private spaces as, for instance, probiotic health products, food, and even do-it-yourself bioengineered systems. What additional steps, if any, should be taken before releasing engineered self-replicating organisms into a broader user space? In this review, we explain how studies of genetically modified organisms lay groundwork for the future landscape of biosafety. Early in the design proc

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  5. Synthetic organisms and living machines

    Anna Deplazes‐Zemp, Markus Huppenbauer · 2009 · Systems and Synthetic Biology · 87 citations

    The difference between a non-living machine such as a vacuum cleaner and a living organism as a lion seems to be obvious. The two types of entities differ in their material consistence, their origin, their development and their purpose. This apparently clear-cut borderline has previously been challenged by fictitious ideas of "artificial organism" and "living machines" as well as by progress in technology and breeding. The emergence of novel technologies such as artificial life, nanobiotechnology and synthetic biology are definitely blurring the boundary between our understanding of living and non-living matter. This essay discusses where, at the borderline between living and non-living matt

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  6. Using Synthetic Biology to Engineer Spatial Patterns

    Javier Santos‐Moreno, Yolanda Schaerli · 2018 · Advanced Biosystems · 84 citations

    Synthetic biology has emerged as a multidisciplinary field that provides new tools and approaches to address longstanding problems in biology. It integrates knowledge from biology, engineering, mathematics, and biophysics to build-rather than to simply observe and perturb-biological systems that emulate natural counterparts or display novel properties. The interface between synthetic and developmental biology has greatly benefitted both fields and allowed to address questions that would remain challenging with classical approaches due to the intrinsic complexity and essentiality of developmental processes. This Progress Report provides an overview of how synthetic biology can help to underst

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  13. Synthetic biology in multicellular organisms: Opportunities in nematodes

    Dmytro Kukhtar, Martin Fussenegger · 2023 · Biotechnology and Bioengineering · 8 citations

    Synthetic biology has mainly focused on introducing new or altered functionality in single cell systems: primarily bacteria, yeast, or mammalian cells. Here, we describe the extension of synthetic biology to nematodes, in particular the well-studied model organism Caenorhabditis elegans, as a convenient platform for developing applications in a multicellular setting. We review transgenesis techniques for nematodes, as well as the application of synthetic biology principles to construct nematode gene switches and genetic devices to control motility. Finally, we discuss potential applications of engineered nematodes.

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  23. Growing Long-chain Polymers in vitro Using Engineered Bacteria in Synthetic Biology and Precision Fermentation Space

    Pranav Bhaskar · 2024 · The Applied Biology & Chemistry Journal

    The synthesis of long-chain polymers has a conventional method of utilizing energy-intensive chemical procedures, which are normally not eco-friendly. Though synthesizing polymers using synthetic biology and precision fermentation is not possible in vitro, both methods, when integrated, provide a biological solution to synthesize polymers in vitro. In light of this, this article examines the means of engineering bacteria, including Escherichia coli and Pseudomonas, that are used to produce controlled synthesis of high-value polymers like PHAs and PLA. New technologies and methodologies of synthetic biology, including the CRISPR-Cas9 system, have brought bacterial metabolic engineering to new

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