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Research papers on Probiotics and gut health

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  1. Gut microbiome and human health: Exploring how the probiotic genus Lactobacillus modulate immune responses

    Sonakshi Rastogi, Aditi Singh · 2022 · Frontiers in Pharmacology · 328 citations

    The highest density of microbes resides in human gastrointestinal tract, known as “Gut microbiome”. Of note, the members of the genus Lactobacillus that belong to phyla Firmicutes are the most important probiotic bacteria of the gut microbiome. These gut-residing Lactobacillus species not only communicate with each other but also with the gut epithelial lining to balance the gut barrier integrity, mucosal barrier defence and ameliorate the host immune responses. The human body suffers from several inflammatory diseases affecting the gut, lungs, heart, bone or neural tissues. Mounting evidence supports the significant role of Lactobacillus spp. and their components (such as metabolites, pepti

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  2. Probiotics, Prebiotics, Synbiotics, and Fermented Foods as Potential Biotics in Nutrition Improving Health via Microbiome-Gut-Brain Axis

    Divakar Dahiya, Poonam Singh Nee Nigam · 2022 · Fermentation · 156 citations

    Biological, social, and psychological practices greatly affect the dietary intake of people; as a result, health-related complexities occur. Functional food and supplements have become popular due to their nutraceutical benefits, which make different choices of fermented food and beverages available to people. This review describes the characteristics of probiotics, prebiotics, post- and paraprobiotics, and their role in nutrition and in the sustainability of health. Currently, several synbiotic supplements have attracted consumers in the nutraceutical market to offer a number of health benefits, which are complementary mixtures of selected characterized probiotic cultures and prebiotic subs

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  4. Probiotic supplementation and associated infant gut microbiome and health: a cautionary retrospective clinical comparison

    Candice Quin, Mehrbod Estaki, Deanna M. Vollman, et al. · 2018 · Scientific Reports · 130 citations

    While probiotics are a multi-billion dollar industry, there is little evidence to show that supplementing infants provides any health benefits. We conducted an observational study where 35 of 86 participating mothers self-administered probiotics during breastfeeding, as well as directly to their infants. The primary objective was to determine if probiotic exposure influenced the infants' fecal microbiome while the secondary objective assessed associated changes to the mothers' breast milk immunity and infant health. Analysis of infant fecal microbiome throughout the first 6 months of life revealed that probiotics were associated with higher abundances of Bifidobacterium at week 1 only. Short

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  5. Probiotics in Poultry: Unlocking Productivity Through Microbiome Modulation and Gut Health

    Muhammad Naeem, D.V. Bourassa · 2025 · Microorganisms · 122 citations

    This review explores the role of probiotics in improving productivity and gut health in poultry through microbiome modulation, particularly during early life. Gut health is pivotal to poultry performance, influencing nutrient absorption, immune function, and disease resistance. Early-life interventions target the microbiome to shape long-term health and productivity. Probiotics, live microorganisms providing health benefits, improve gut health through the competitive exclusion of pathogens, immune modulation, antimicrobial compound production, and enhancing gut barrier integrity. Applying probiotics improves growth performance, feed conversion efficiency, body weight gain, and carcass qualit

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  6. Yeast Probiotics Shape the Gut Microbiome and Improve the Health of Early-Weaned Piglets

    Xu JinQiang, Yuhui Li, Zhiqiang Yang, et al. · 2018 · Frontiers in Microbiology · 89 citations

    Weaning is one of the most stressful challenges in the pig’s life, which contributes to dysfunctions of intestinal and immune system, disrupts the gut microbial ecosystem, and therefore compromises the growth performance and health of piglets. To mitigate the negative impact of the stress on early-weaned piglets, effective measures are needed to promote gut health. Toward this end, we tamed a Saccharomyces cerevisiae strain and developed a probiotic Duan-Nai-An, which is a yeast culture of the tamed Saccharomyces cerevisiae on egg white. In this study, we tested the performance of Duan-Nai-An on growth and health of early-weaned piglets and analyzed its impact on fecal microbiota. The result

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  7. Understanding how pre- and probiotics affect the gut microbiome and metabolic health

    Patrícia Martins Bock, Andreza Francisco Martins, Beatriz D'Agord Schaan · 2024 · American Journal of Physiology-Endocrinology and Metabolism · 67 citations

    The gut microbiome, a complex assembly of microorganisms, significantly impacts human health by influencing nutrient absorption, the immune system, and disease response. These microorganisms form a dynamic ecosystem that is critical to maintaining overall well-being. Prebiotics and probiotics are pivotal in regulating gut microbiota composition. Prebiotics nourish beneficial bacteria and promote their growth, whereas probiotics help maintain balance within the microbiome. This intricate balance extends to several aspects of health, including maintaining the integrity of the gut barrier, regulating immune responses, and producing metabolites crucial for metabolic health. Dysbiosis, or an imba

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  12. Microbiome–mycotoxin interactions and probiotic strategies: implications for gut health and cancer

    Alice Njolke Mafe, Dietrich Büsselberg · 2026 · Frontiers in Nutrition · 11 citations

    This structured, hypothesis-driven narrative review examines how mycotoxins, pervasive food contaminants, disrupt intestinal microbial balance, epithelial barrier integrity, xenobiotic metabolism, and carcinogenic signaling. Emerging evidence indicates that bidirectional interactions between the gut microbiome and mycotoxins modulate these effects, with microbial detoxification enzymes influencing toxin metabolism, immune responses, and epithelial resilience. However, the mechanistic understanding of microbiome-mycotoxin interplay remains incomplete, particularly regarding enzymatic pathways, microbial metabolites, and cancer-associated signaling. This review synthesizes recent (2016-2025) m

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  13. Gut bioengineered models to study host-microbiota-probiotics interactions

    Elise Delannoy, Alexandre Grassart, Catherine Daniel · 2025 · Microbiome Research Reports · 4 citations

    The gastrointestinal tract is the major ecological niche in which gut microbes interact with epithelial and immune cells to maintain homeostasis in mammals. Moreover, probiotics modulate the gut microbiota and exert various health benefits after oral administration and persistence in the gut. Until now, animal models have been the gold standard for unravelling the mechanisms implicated in host-microbe interactions. However, their translational relevance to clinical trials and the associated ethical concerns underscore the need for alternative models. The emergence of microfluidic organ-on-chip technologies provides promising new alternative models to explore human host-microbe interactions w

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  14. Probiotics and Gut Microbiome Health

    Mahendra Singh Pal · 2025 · Nutrition and Food Processing

    Recent years have witnessed the global upsurge in the use of probiotics by people as they realized several health benefits. The health of the gut microbiome contributes to the well-being of the human body and the prevention of some diseases. Probiotics, prebiotics and other beneficial components taken in during a healthy diet help to balance the gut microbiome. The probiotics play a significant role both in the prevention and treatment of stomach and intestinal complaints, mental diseases, COVID-19, cancer, and anemia. Yoghurt is considered as a very good source of probiotics, and it should preferably be consumed in the morning. Probiotics manufactured by several pharmaceuticals, are easily

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  15. GUT HEALTH MANAGEMENT IN POULTRY: PROBIOTICS TO SYNTHETIC MICROBIOMES

    Kavin Prasath A P, Kamali Mariyastepy J, Kutraaleswaran T · 2026 · Iterative International Publishers eBooks

    Poultry rearing has shifted from a traditional system to modern industrial setup. Gut is the major organ associated with nutrient absorption and productivity. It harbours a variety of microbes and their manipulation can positively impact productivity. Traditionally it is achieved by antibiotics. Due to rise in antimicrobial resistance awareness the focus on antibiotics has shifted to microbial supplements such as probiotics, prebiotics, synbiotics, postbiotics, parabiotics, eubiotics, fermented feeds and the novel concept of synthetic microbiome. Prebiotics as a substrate promotes growth of beneficial microbes, reducing pathogens and improving productivity. Probiotics as a live microbial sup

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