FolioStart free

Health · Literature

Research papers on Vitamin D deficiency

Recent and highly-cited academic work on vitamin d deficiency, gathered from Semantic Scholar, CrossRef and OpenAlex.

Search all 200M+ papers on this topic, free →Or track new vitamin d deficiency papers automatically as they publish

  1. The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration

    Alessandro Liberati, Douglas G. Altman, Jennifer Tetzlaff, et al. · 2009 · PLoS Medicine · 28,047 citations

    Systematic reviews and meta-analyses are essential to summarize evidence relating to efficacy and safety of health care interventions accurately and reliably. The clarity and transparency of these reports, however, is not optimal. Poor reporting of systematic reviews diminishes their value to clinicians, policy makers, and other users.Since the development of the QUOROM (QUality Of Reporting Of Meta-analysis) Statement--a reporting guideline published in 1999--there have been several conceptual, methodological, and practical advances regarding the conduct and reporting of systematic reviews and meta-analyses. Also, reviews of published systematic reviews have found that key information about

    Save this paper

  2. Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury.

    Changmeng Cui, Jianzhong Cui, Feng Jin, et al. · 2017 · PubMed · 5,191 citations

    BACKGROUND/AIMS: Traumatic brain injury (TBI) is a major public health problem in the world and causes high rates of mortality and disability. Recent evidence suggests that vitamin D (VD) has neuroprotective actions and can promote function recovery after TBI. In vitro and in vivo studies have demonstrated that autophagy could be enhanced following supplementation with an active metabolite of VD (calcitriol). However, it is unclear whether autophagy participates in the protective effects of calcitriol after TBI. To test this hypothesis, we examined the protective effects of calcitriol on TBI-induced neurological impairment and further investigated whether calcitriol could modulate autophagy

    Save this paper

  4. Vitamin D Deficiency and Risk of Cardiovascular Disease

    Thomas J. Wang, Michael J. Pencina, Sarah L. Booth, et al. · 2008 · Circulation · 2,397 citations

    BACKGROUND: Vitamin D receptors have a broad tissue distribution that includes vascular smooth muscle, endothelium, and cardiomyocytes. A growing body of evidence suggests that vitamin D deficiency may adversely affect the cardiovascular system, but data from longitudinal studies are lacking. METHODS AND RESULTS: We studied 1739 Framingham Offspring Study participants (mean age 59 years; 55% women; all white) without prior cardiovascular disease. Vitamin D status was assessed by measuring 25-dihydroxyvitamin D (25-OH D) levels. Prespecified thresholds were used to characterize varying degrees of 25-OH D deficiency (< 15 ng/mL, < 10 ng/mL). Multivariable Cox regression models were adjusted fo

    Save this paper

  5. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths

    William B. Grant, Henry Lahore, Sharon L. McDonnell, et al. · 2020 · Nutrients · 2,009 citations

    The world is in the grip of the COVID-19 pandemic. Public health measures that can reduce the risk of infection and death in addition to quarantines are desperately needed. This article reviews the roles of vitamin D in reducing the risk of respiratory tract infections, knowledge about the epidemiology of influenza and COVID-19, and how vitamin D supplementation might be a useful measure to reduce risk. Through several mechanisms, vitamin D can reduce risk of infections. Those mechanisms include inducing cathelicidins and defensins that can lower viral replication rates and reducing concentrations of pro-inflammatory cytokines that produce the inflammation that injures the lining of the lung

    Save this paper

  6. Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice

    Roger Bouillon, Geert Carmeliet, Lieve Verlinden, et al. · 2008 · Endocrine Reviews · 1,788 citations

    The vitamin D endocrine system is essential for calcium and bone homeostasis. The precise mode of action and the full spectrum of activities of the vitamin D hormone, 1,25-dihydroxyvitamin D [1,25-(OH)(2)D], can now be better evaluated by critical analysis of mice with engineered deletion of the vitamin D receptor (VDR). Absence of a functional VDR or the key activating enzyme, 25-OHD-1alpha-hydroxylase (CYP27B1), in mice creates a bone and growth plate phenotype that mimics humans with the same congenital disease or severe vitamin D deficiency. The intestine is the key target for the VDR because high calcium intake, or selective VDR rescue in the intestine, restores a normal bone and growth

    Save this paper

  12. Vitamin D Deficiency Leads to Poorer Health Outcomes and Greater Length of Stay After Total Knee Arthroplasty and Supplementation Improves Outcomes

    Kavyesh Vivek, Rayan Kamal, Edward Perera, et al. · 2024 · JBJS Reviews · 18 citations

    Background: Vitamin D deficiency is increasingly identified as a predictor of poorer outcomes in musculoskeletal disease affecting as many as 1 in 4 people. This study aimed to evaluate the effect of vitamin D supplementation on outcomes after primary total knee arthroplasty (TKA). Methods: A targeted search of terms related to vitamin D and TKA outcomes was performed in PubMed, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, American Academy of Orthopaedic Surgeons, and British Orthopaedic Association databases. The results were an

    Save this paper

  16. Asthmatic patients with vitamin D deficiency: Can vitamin D supplementation make a difference

    Haiying Niu, Huijie He, Zilong Zhao, et al. · 2024 · Technology and Health Care · 4 citations

    BACKGROUND: Asthma is a major public health concern due to its persistent inflammation of the airways. The intricate and widely variable epidemiology of asthma among nations and populations is a result of the interplay between genetic, environmental, and socioeconomic factors. OBJECTIVE: This study aims to investigate whether VitD supplementation can reduce the frequency of exacerbations (including the frequency of exacerbations requiring systemic corticosteroids and the frequency of exacerbations necessitating trips to the hospital or emergency room, or both) and improve pulmonary function (clinical indicators such as the FEV1% predicted value). METHODS: Computers were used to search Pubmed

    Save this paper

  19. Supplementation of vitamin D in children with obesity and vitamin D deficiency - review of outcomes in terms of obesity parameters and comorbidities

    Weronika Kamińska, Adrian Bobrzyk, Grzegorz Łyko, et al. · 2023 · Journal of Education, Health and Sport · 2 citations

    In recent years, vitamin D deficiency and obesity in paediatric population have reached epidemic levels worldwide as crucial health concerns with far-reaching consequences. There has been a substantial growth in studies dedicated to these two public health issues over the last years. Numerous studies have confirmed that excess body weight has negative impact on vitamin D metabolism, leading to a higher risk of low levels of this essential vitamin, among individuals who are overweight or obese. Vitamin D deficiency may play a role in the development of obesity-related conditions as insulin resistance, type two diabetes, NAFLD and cardiovascular disease due to anti-inflammatory properties, imp

    Save this paper

  20. Vitamin D supplementation influences the serum lipid profile in the Jordanian population with vitamin D deficiency

    Saad Alfawaeir · 2025 · Nutrición Clínica y Dietética Hospitalaria · 1 citations

      Purpose: To evaluate the association between vitamin D supplementation and changes in lipid profile in a Jordanian population with vitamin D deficiency. Methodology: A total of 95 participants, comprising 35 females aged 15-73 years, were recruited for this prospective investigation and administered vitamin D supplements. Blood specimens were examined for lipid profile characteristics and 25(OH)D3 amounts. Vitamin D supplementation protocole involved the weekly dosing of a single tablet containing 50,000 IU of cholecalciferol for the first four weeks, and bi-weekly medication for the final four weeks. Findings: Before intervention, vitamin D, calcium, total cholesterol, high-density lipopr

    Save this paper

Write your paper with these sources

Folio is the integrity-first research workspace: search 200M+ papers, save sources, and write with citations that format themselves. Free for students and researchers.

Start writing free →